Pharmacology of a mimetic of glutathione disulfide, NOV-002
نویسندگان
چکیده
منابع مشابه
Pharmacology of a mimetic of glutathione disulfide, NOV-002.
NOV-002 is a novel therapeutic agent in development for oncology indications used in combination with chemotherapy. Clinical trials in Russia and the USA have demonstrated clinical activity and the present focus is on non-small cell lung cancer (NSCLC) patients. The active component of the drug is oxidized glutathione (GSSG) and this imparts multiple effects upon redox pathways both at the cell...
متن کاملCellular Redox Balance NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Updated Version
NOV-002 is a novel glutathione disulfide mimetic that when administered in combination with standard chemotherapeutic regimens has resulted in increased efficacy (survival, tumor response) and improved tolerance to chemotherapy (e.g., hematologic recovery) in advanced non–small cell lung cancer patients. We show that NOV-002, which is not cytotoxic as a single agent, generated timeand concentra...
متن کاملNOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance.
NOV-002 is a novel glutathione disulfide mimetic that when administered in combination with standard chemotherapeutic regimens has resulted in increased efficacy (survival, tumor response) and improved tolerance to chemotherapy (e.g., hematologic recovery) in advanced non-small cell lung cancer patients. We show that NOV-002, which is not cytotoxic as a single agent, generated time- and concent...
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Metastasis is the major cause of death in cancer. Most therapies currently in the clinic aim to eradicate primary tumor, but do not have ideal effects on metastasis. The lack of effective therapy in metastasis prevention and treatment results in high mortality rate in cancer patients with advanced diseases. Here we report the oxidized glutathione small molecule compound NOV-002 reduces cancer c...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2009
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2008.08.019